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期刊论文 53

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不良妊娠结局 1

主成分分析网络 1

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子带瞬时能量谱 1

孕前优生健康检查 1

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工业信息物理系统；水处理系统；入侵检测；异常状态；检测和定位；信息论 1

异常事件检测 1

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Assessment of robustness of structures: Current state of research

Colin BRETT, Yong LU

《结构与土木工程前沿（英文）》 2013年 第7卷 第4期   页码 356-368 doi: 10.1007/s11709-013-0220-z

摘要： The concept of structural robustness and relevant design guidelines have been in existence in the progressive collapse literature since the 1970s following the partial collapse of the Ronan Point apartment building; however, in the more general context, research on the evaluation and enhancement of structural robustness is still relatively limited. This paper is aimed to provide a general overview of the current state of research concerning structural robustness. The focus is placed on the quantification and the associated evaluation methodologies, rather than specific measures to ensure prescriptive robustness requirements. Some associated concepts, such as redundancy and vulnerability, will be discussed and interpreted in the general context of robustness such that the corresponding methodologies can be compared quantitatively using a comparable scale. A framework methodology proposed by the authors is also introduced in line with the discussion of the literature.

关键词： structural robustness     abnormal exposure     vulnerability     collapse     consequence    

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Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship

Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu

《医学前沿（英文）》 2021年 第15卷 第5期   页码 649-656 doi: 10.1007/s11684-021-0830-0

摘要： Tumorigenesis involves metabolic reprogramming and abnormal lipid metabolism, which is manifested by increased endogenous fat mobilization, hypertriglyceridemia, and increased fatty acid synthesis. Fatty acid synthase (FASN) is a key enzyme for the synthesis of fatty acids, and monoacylglycerol esterase (MGLL) is an important metabolic enzyme that converts triglycerides into free fatty acids. Both enzymes play an important role in lipid metabolism and are associated with tumor-related signaling pathways, the most common of which is the PI3K–AKT signaling pathway. They can also regulate the immune microenvironment, participate in epithelial–mesenchymal transition, and then regulate tumor invasion and metastasis. Current literature have shown that these two genes are abnormally expressed in many types of tumors and are highly correlated with tumor migration and invasion. This article introduces the structures and functions of FASN and MGLL, their relationship with abnormal lipid metabolism, and the mechanism of the regulation of tumor invasion and metastasis and reviews the research progress of the relationship of FASN and MGLL with tumor invasion and metastasis.

关键词： FASN     MGLL     lipid metabolism     tumor invasion     metastasis    

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Long-term exposure to air pollution and cerebrovascular disease: findings from Beijing Health Management

《环境科学与工程前沿（英文）》 2023年 第17卷 第7期 doi: 10.1007/s11783-023-1684-2

摘要：

● This study explored the long-term association by double robust additive models.

关键词： Air pollution     Cerebrovascular disease     Incidence     Long-term exposure     Doubly robust additive model    

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Untargeted metabolomic analysis of pregnant women exposure to perfluorooctanoic acid at different degrees

《环境科学与工程前沿（英文）》 2023年 第17卷 第3期 doi: 10.1007/s11783-023-1628-x

摘要：

● Metabolome can distinguish pregnant women exposure to PFOA at different degrees.

关键词： Perfluorooctanoic acid     Exposure     Pregnant women     Metabolomic     GSH     Microbiota metabolism    

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Identification of abnormal operating conditions and intelligent decision system

Xiuliang LI, Junjie JIANG, Hongye SU, Jian CHU

《机械工程前沿（英文）》 2011年 第6卷 第4期   页码 456-462 doi: 10.1007/s11465-011-0224-0

摘要：

In earth pressure balance (EPB) shield construction, the “plastic flow state” is difficult to form using the soil dug in the capsule because it can cause three abnormal operating conditions, including occlusion, caking in the capsule, and spewing at the outlet of the dump device. These abnormal operating conditions can, in turn, trigger failure in tunneling, cutter-device damage, and even catastrophic incidents, such as ground settlement. This present paper effectively integrates the mechanism of abnormal operating conditions and knowledge of soil conditioning, and establishes a uniform model of identifying abnormal conditions and intelligent decision support system based on the belief rule-base system. The model maximizes knowledge in improving the soil, construction experience, and data to optimize the model online. Finally, a numerical simulation with specific construction data is presented to illustrate the effectiveness of the algorithm.

关键词： earth pressure balance (EPB) shield machine     soil pressure cabin     abnormal operating condition     belief rule-base system    

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Ultraviolet exposure enhanced silicon direct bonding

Guanglan LIAO, Xuekun ZHANG, Xiaohui LIN, Canghai MA, Lei NIE, Tielin SHI,

《机械工程前沿（英文）》 2010年 第5卷 第1期   页码 87-92 doi: 10.1007/s11465-009-0078-x

摘要： Ultraviolet (UV) exposure, as an additional technique following the traditional wet chemical activation processes, is applied to enhance hydrophilic silicon direct bonding. The effects of UV exposure on silicon wafers’ nano-topography and bonding strength are studied. It is found that the surface roughness of silicon wafers initially decreases and then increases with UV exposure time, and the bonding strength increases and then decreases accordingly. The correlations of annealing temperature and annealing time vs. bonding strength are experimentally explored. Results indicate that the bonding strength increases sharply then gently with increasing annealing temperature and annealing time using UV exposure. Besides, the reliability of silicon direct bonding with UV exposure enhancement after the high/low temperature cycle test, constant temperature and humidity test, vibration test and shock test is investigated. It follows from the results that the bonding strength of silicon wafer pairs with UV exposure decreases after the environmental tests, whereas the residual strength is still higher than that without UV exposure, and the variation trends of bonding strength vs. UV exposure time, annealing temperature and annealing time remain unchanged. Therefore, following the traditional wet chemical activation processes, appropriate UV exposure (about three minutes in this study) is effective and promising to enhance silicon direct bonding.

关键词： ultraviolet (UV) exposure     silicon direct bonding     bonding strength     reliability    

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Paternal environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational

《医学前沿（英文）》 2022年 第16卷 第2期   页码 176-184 doi: 10.1007/s11684-021-0885-y

摘要： Studies of human and mammalian have revealed that environmental exposure can affect paternal health conditions as well as those of the offspring. However, studies that explore the mechanisms that meditate this transmission are rare. Recently, small noncoding RNAs (sncRNAs) in sperm have seemed crucial to this transmission due to their alteration in sperm in response to environmental exposure, and the methodology of microinjection of isolated total RNA or sncRNAs or synthetically identified sncRNAs gradually lifted the veil of sncRNA regulation during intergenerational inheritance along the male line. Hence, by reviewing relevant literature, this study intends to answer the following research concepts: (1) paternal environmental factors that can be passed on to offspring and are attributed to spermatozoal sncRNAs, (2) potential role of paternal spermatozoal sncRNAs during the intergenerational inheritance process, and (3) the potential mechanism by which spermatozoal sncRNAs meditate intergenerational inheritance. In summary, increased attention highlights the hidden wonder of spermatozoal sncRNAs during intergenerational inheritance. Therefore, in the future, more studies should focus on the origin of RNA alteration, the target of RNA regulation, and how sncRNA regulation during embryonic development can be sustained even in adult offspring.

关键词： small noncoding RNAs     epigenetic inheritance     paternal intergenerational inherence     extracellular vesicles    

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Feedback linearization based control for weak grid connected PV system under normal and abnormal conditions

Rahul SHARMA,Sathans SUHAG

《能源前沿（英文）》 2020年 第14卷 第2期   页码 400-409 doi: 10.1007/s11708-017-0459-5

摘要： This paper proposes a control strategy for interface of distributed energy sources into the weak grid system with a focus on the energy and ancillary services. A novel controller has been designed and implemented to tackle the challenges of coupling terms in the LCL filter, the transient behavior under sudden changes, and the voltage support under fault condition using the feedback linearization technique. The controller proposed has been implemented on the PV system connected with the weak grid using the LCL filter and the performance of the controller has been verified using Matlab/Simulink through simulation under different conditions. The results of the controller proposed have been compared with the conventional PI dual loop controller. The simulation results obtained demonstrate the effectiveness and simplicity of the controller design strategy.

关键词： PV system     grid interface     feedback linearization     inverter     LCL filter    

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Study of blood exposure-related mental health illness among clinical nurses

null

《医学前沿（英文）》 2017年 第11卷 第1期   页码 147-151 doi: 10.1007/s11684-016-0481-8

摘要：

Nurses are subjected to high amount of stress in the medical setting, and work-related stress often leads to mental problems. This study aims to investigate the mental health status of nurses exposed to blood through needlestick injuries. A total of 302 nurses working in the hospital of Guangdong, China, participated in this study. Out of the 302 nurses, 140 did not experience any needlestick injuries during the previous week, whereas 162 nurses experienced needlestick injuries. The General Health Questionnaire (GHQ)-28 Standardized Questionnaire, which uses physical, anxiety, social function, and depression subscales, was used in this study. No significant difference between nurses exposed to blood and nurses not exposed to blood was found in terms of gender, age, length of employment, and civil status (P>0.05). Results from the GHQ-28 Standardized Questionnaire showed that 75.9% (123/162) of nurses exposed to blood were suspected to suffer from mental disorders, whereas 40% (56/140) of nurses not exposed to blood were suspected to suffer from mental disorders. The mean mental health scores of nurses exposed to blood and those not exposed were 8.73±7.32 and 5.69±5.70, respectively. From these results, we can conclude that blood exposure from needlestick injuries leads to higher prevalence of depression, anxiety, and stress symptoms in nurses. This finding highlights the importance of providing efficient, adequate, and appropriate support services after nurses are exposed to blood from needlestick injuries.

关键词： blood exposure     needlestick injuries     mental health     nurses    

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A knowledge reasoning Fuzzy-Bayesian network for root cause analysis of abnormal aluminum electrolysis

Weichao Yue, Xiaofang Chen, Weihua Gui, Yongfang Xie, Hongliang Zhang

《化学科学与工程前沿（英文）》 2017年 第11卷 第3期   页码 414-428 doi: 10.1007/s11705-017-1663-x

摘要： Root cause analysis (RCA) of abnormal aluminum electrolysis cell condition has long been a challenging industrial issue due to its inherent complexity in analyzing based on multi-source knowledge. In addition, accurate RCA of abnormal aluminum electrolysis cell condition is the precondition of improving current efficiency. RCA of abnormal condition is a complex work of multi-source knowledge fusion, which is difficult to ensure the RCA accuracy of abnormal cell condition because of dwindling and frequent flow of experienced technicians. In view of this, a method based on Fuzzy-Bayesian network to construct multi-source knowledge solidification reasoning model is proposed. The method can effectively fuse and solidify the knowledge, which is used to analyze the cause of abnormal condition by technicians providing a clear and intuitive framework to this complex task, and also achieve the result of root cause automatically. The proposed method was verified under 20 sets of abnormal cell conditions, and implements root cause analysis by finding the abnormal state of root node, which has a maximum posterior probability by Bayesian diagnosis reasoning. The accuracy of the test results is up to 95%, which shows that the knowledge reasoning feasibility for RCA of aluminum electrolysis cell.

关键词： abnormal aluminum electrolysis cell condition     Fuzzy-Bayesian network     multi-source knowledge solidification and reasoning     root cause analysis    

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Effects of hemin and thermal stress exposure on JWA expression

ZHAO Ming, CHEN Rui, LI Aiping, ZHOU Jianwei

《医学前沿（英文）》 2007年 第1卷 第1期   页码 104-108 doi: 10.1007/s11684-007-0020-8

摘要： To investigate the expression of JWA after hemin and (or) thermal stress exposure, we treated K562 (chronic myelogenous leukemia cells) cells with different doses of hemin and thermal stress using different exposure times. The expression of JWA protein was determined by Western blot analysis. Reverse transcription-polymerase chain reaction was carried out to determine JWA mRNA expression. JWA promoter transcription activity analysis was performed by chloramphenicol acetyl transferase-enzyme linked immunosorbent assay (CAT-ELISA). The expression of JWA protein was significantly increased by up to (3.23±0.57) folds compared to the control in K562 cells after hemin treatment (50 µM for one week), and a similar pattern was observed in the cells after treatment with thermal stress (42 °C) for 2 hours [increased by (8.00±1.73) folds]. The expression of JWA mRNA was also significantly elevated by up to (1.37±0.06) folds in K562 cells treated with hemin (30 µM for 48 hours), and a similar regulatory pattern [increased by (1.87±0.13) folds] was observed with thermal stress exposure (42 °C) for 30 minutes. However, a combined antagonistic effect was observed in the treatment of K562 cells with hemin (30 µM, 48 h) followed by thermal stress (42 °C, 30 min). CAT-ELISA further confirmed that either hemin or thermal stress treatment could up-regulate JWA transcription activity, however, the effects could be counteracted partly by treatment with a combination of both. Hemin and thermal stress might regulate JWA expression via distinct intracellular signal transduction pathways.
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AED-Net——异常事件检测网络 Article

王田, 苗子琛, 陈禹昕, 周毅, 单光存, Hichem Snoussi

《工程（英文）》 2019年 第5卷 第5期   页码 930-939 doi: 10.1016/j.eng.2019.02.008

摘要：

长期以来，在拥挤场景中检测异常事件都是一项具有挑战性的任务。为解决这一问题，本文提出了一种名叫异常事件检测网络（AED-Net）的自监督框架，它由主成分分析网络（PCANet）和核主成分分析（kPCA）组成。该框架以不同场景的监控视频序列为原始数据，通过训练PCANet以提取人群情况的高级语义。kPCA可作为一种单类分类器，被用于识别场景中的异常事件。与目前流行的一些深度学习方法相比，该框架完全是自监督的，因为它只使用正常情况下的视频序列。通过对明尼苏达大学公共监测人类活动数据集（UMN数据集）和加州大学圣地亚哥分校监测异常数据集（UCSD数据集）进行全局和局部异常事件进行检测发现，与其他最先进的方法相比，该方法具有更好的等误差率（EER）和曲线下面积（AUC）。此外，通过增加局部响应归一化（LRN）层，我们对原有的AED-Net进行了改进。结果表明，该改进版在提高框架的泛化能力方面表现出更好的性能。

关键词： 异常事件检测     异常事件检测网络     主成分分析网络     核主成分分析    

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Occupational risk of exposure to methicillin-resistant (MRSA) and the quality of infection hygiene in

《环境科学与工程前沿（英文）》 2021年 第15卷 第3期 doi: 10.1007/s11783-020-1333-y

摘要：

• Staff members were not colonised with MRSA.

关键词： Antibiotic resistance     Airborne MRSA     Bioaerosols     Healthcare-associated infections     Healthcare worker     Occupational health    

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Universal influenza virus vaccines: what can we learn from the human immune response following exposure

null

《医学前沿（英文）》 2017年 第11卷 第4期   页码 471-479 doi: 10.1007/s11684-017-0602-z

摘要：

Several universal influenza virus vaccine candidates based on eliciting antibodies against the hemagglutinin stalk domain are in development. Typically, these vaccines induce responses that target group 1 or group 2 hemagglutinins with little to no cross-group reactivity and protection. Similarly, the majority of human anti-stalk monoclonal antibodies that have been isolated are directed against group 1 or group 2 hemagglutinins with very few that bind to hemagglutinins of both groups. Here we review what is known about the human humoral immune response to vaccination and infection with H7 subtype influenza viruses on a polyclonal and monoclonal level. It seems that unlike vaccination with H5 hemagglutinin, which induces antibody responses mostly restricted to the group 1 stalk domain, H7 exposure induces both group 2 and cross-group antibody responses. A better understanding of this phenomenon and the underlying mechanisms might help to develop future universal influenza virus vaccine candidates.

关键词： universal influenza virus vaccine     hemagglutinin stalk     H7N9    

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Abnormal glycosylated hemoglobin as a predictive factor for glucose metabolism disorders in antipsychotic

XU Leping, JI Juying, DUAN Yiyang, SHI Hui, ZHANG Bin, SHAO Yaqin, SUN Jian

《医学前沿（英文）》 2007年 第1卷 第3期   页码 316-319 doi: 10.1007/s11684-007-0061-z

摘要： The aim of this study was to observe the changes in glucose metabolism after antipsychotic (APS) therapy, to note the influencing factors, as well as to discuss the relationship between the occurrence of glucose metabolism disorders of APS origin and abnormal glycosylated hemoglobin (HbAc) levels. One hundred and fifty-two patients with schizophrenia, whose fasting plasma glucose (FPG) and 2-h plasma glucose (2hPG) in the oral glucose tolerance test (2HPG) were normal, were grouped according to the HbAc levels, one normal and the other abnormal, and were randomly enrolled into risperidone, clozapine and chlorpromazine treatment for six weeks. The FPG and 2hPG were measured at the baseline and at the end of the study. In the group with abnormal HbA1c and clozapine therapy, 2HPG was higher after the study [(9.5±1.8) mmol/L] than that before the study [(7.2±1.4) mmol/L] and the difference was statistically significant (〈0.01). FPG had no statistically significant difference before and after the study in any group (〉0.05). HbAc levels and drugs contributing to 2HPG at the end of study had statistical cross-action (〈0.01). In the abnormal HbAc group, 2HPG after the study was higher in the clozapine treatment group [(9.5±1.8) mmol/L] than in the risperidone treatment group [(7.4±1.7) mmol/L] and the chlorpromazine treatment group [(7.3±1.6) mmol/L]. The differences were statistically significant (〈0.01). In the normal HbAc group there was no statistically significant difference before and after the study in any group (〉0.05). 2HPG before [(7.1±1.6) mmol/L] and after the study [(8.1±1.9) mmol/L] was higher in the abnormal HbAc group than in the normal HbAc group [(6.2±1.4) mmol/L (6.5±1.4) mmol/L] with the difference being statistically significant (〈0.01 〈0.001). As compared with normal HbAc group, the relative risk (RR) of glucose metabolism disease occurrence was 4.7 in the abnormal HbAc group with the difference being statistically significant (〈0.001). Patients with abnormal HbAc are more likely to have a higher risk of having glucose metabolism disorders after APS treatment.

关键词： significant difference     occurrence     hemoglobin     risperidone treatment     abnormal    

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标题 作者 时间 类型 操作

Assessment of robustness of structures: Current state of research

Colin BRETT, Yong LU

期刊论文

Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship

Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu

期刊论文

Long-term exposure to air pollution and cerebrovascular disease: findings from Beijing Health Management

期刊论文

Untargeted metabolomic analysis of pregnant women exposure to perfluorooctanoic acid at different degrees

期刊论文

Identification of abnormal operating conditions and intelligent decision system

Xiuliang LI, Junjie JIANG, Hongye SU, Jian CHU

期刊论文

Ultraviolet exposure enhanced silicon direct bonding

Guanglan LIAO, Xuekun ZHANG, Xiaohui LIN, Canghai MA, Lei NIE, Tielin SHI,

期刊论文

Paternal environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational

期刊论文

Feedback linearization based control for weak grid connected PV system under normal and abnormal conditions

Rahul SHARMA,Sathans SUHAG

期刊论文

Study of blood exposure-related mental health illness among clinical nurses

null

期刊论文

A knowledge reasoning Fuzzy-Bayesian network for root cause analysis of abnormal aluminum electrolysis

Weichao Yue, Xiaofang Chen, Weihua Gui, Yongfang Xie, Hongliang Zhang

期刊论文

Effects of hemin and thermal stress exposure on JWA expression

ZHAO Ming, CHEN Rui, LI Aiping, ZHOU Jianwei

期刊论文

AED-Net——异常事件检测网络

王田, 苗子琛, 陈禹昕, 周毅, 单光存, Hichem Snoussi

期刊论文

Occupational risk of exposure to methicillin-resistant (MRSA) and the quality of infection hygiene in

期刊论文

Universal influenza virus vaccines: what can we learn from the human immune response following exposure

null

期刊论文

Abnormal glycosylated hemoglobin as a predictive factor for glucose metabolism disorders in antipsychotic

XU Leping, JI Juying, DUAN Yiyang, SHI Hui, ZHANG Bin, SHAO Yaqin, SUN Jian

期刊论文